Systemic Triple Therapy in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Ready for Prime Time or Still to Be Explored?
Christian ThomasMartin BaunackeHolger Hans Hermann ErbSusanne FüsselKati ErdmannJuliane PutzAngelika BorkowetzPublished in: Cancers (2021)
For decades, mono androgen deprivation therapy (ADT) has been the gold standard for metastatic hormone-sensitive prostate cancer (mHSPC) treatment. Several studies have been published within the last seven years demonstrating a significant survival advantage by combination treatment with standard ADT plus docetaxel or androgen receptor-axis-targeted therapy (ARAT) compared to ADT monotherapy. As a result, overall survival can be prolonged by at least 18 months. Recently published congress data of the PEACE-1 study suggests that in the future, triple therapy might be the new gold standard. In addition to this study, which has shown that triple treatment with standard ADT plus docetaxel plus abiraterone is superior to standard ADT plus docetaxel, several other phase III triple therapy studies are currently ongoing. The different modes of action that are investigated reach from AR-targeting over mitotic inhibition and immunotherapy to PARP and AKT inhibition. In this review we will explore if triple therapy has the potential to be the new standard for mHSPC treatment in the near future.
Keyphrases
- prostate cancer
- squamous cell carcinoma
- small cell lung cancer
- clinical trial
- combination therapy
- systematic review
- stem cells
- signaling pathway
- open label
- climate change
- oxidative stress
- replacement therapy
- mesenchymal stem cells
- bone marrow
- mass spectrometry
- deep learning
- smoking cessation
- cell therapy
- artificial intelligence
- silver nanoparticles
- drug induced
- high speed