Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson's disease.

Edward J R FletcherLawrence D F MoonSusan Duty

Published in: BMC neuroscience (2019)

ChABC treatment provided significant protection against a partial 6-OHDA lesion of the nigrostriatal tract although the degree of protection was not sufficient to improve motor outcomes. These results support further investigations into the benefits of ChABC treatment for providing neuroprotection in PD.

Keyphrases

cell death
mouse model
brain injury
metabolic syndrome
cell proliferation
signaling pathway
cell cycle arrest
deep brain stimulation