Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.

Jakub SkałbaniaArtur PałaszIwona BłaszczykAleksandra Suszka-ŚwitekMarek KrzystanekKarina Paola TulcanazJohn J WorthingtonKinga Mordecka-Chamera

Published in: Pharmacological reports : PR (2021)

Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
transcription factor
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway
combination therapy
replacement therapy