Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice.

Ben VanderkrukNina MaeshimaDaniel J Pasula Meilin An Cassandra L McDonald Priya Suresh Dan S Luciani Francis C Lynn Brad G Hoffman

Published in: Diabetologia (2023)

Sustained methylation of H3K4 is critical for the maintenance of beta cell function. Redistribution of H3K4me3 is linked to gene expression changes that are implicated in diabetes pathology.

Keyphrases

gene expression
dna methylation
genome wide
type diabetes
cardiovascular disease
high fat diet induced
glycemic control
metabolic syndrome
amino acid
skeletal muscle
childhood cancer