F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway.

Zhiqin CaoKeke ZhangJingruo LiuYu PanJiayi ShiLuxin LiXiaocan SunShiqi LiXiaohuan YuanDan Wu

Published in: Molecular medicine (Cambridge, Mass.) (2024)

F127-SE-tLAP could increase the transdermal delivery of LAP, reduce the production and deposition of ECM, inhibit the formation of dermal collagen fibers, and alleviate the progression of skin fibrosis. It may provide a new idea for the therapy of skin fibrosis.

Keyphrases

wound healing
soft tissue
transforming growth factor
epithelial mesenchymal transition
diabetic rats
stem cells
tissue engineering
bone marrow
mesenchymal stem cells
signaling pathway
cell therapy
pulmonary fibrosis
stress induced
smoking cessation