Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation.

Han ZhouLei WangZhiwen LinChenwei JiangXingte ChenKai WangLibin LiuLingdong ShaoJianji PanJinluan LiDa ZhangJunxin Wu

Published in: Journal for immunotherapy of cancer (2023)

Our research indicates that MG shows promise as a radiosensitizer and immunomodulator for RC. Furthermore, we propose that combining MG with iRT has great potential for clinical practice.

Keyphrases

endoplasmic reticulum stress
rectal cancer
clinical practice
induced apoptosis
locally advanced
big data
human health
radiation therapy
signaling pathway
machine learning
risk assessment
oxidative stress
deep learning
artificial intelligence