Protein kinase B (AKT) upregulation and Thy-1-α v β 3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.

Ramón Pérez-NúñezAlejandro ChamorroMaría Fernanda GonzálezPamela ContrerasRocío ArtigasAlejandro H Corvalán Brigitte van ZundertChristopher ReyesPablo R MoyaAna María AvalosPascal Schneider Andrew Frederick Geoffery Quest Lisette Leyton

Published in: Journal of neuroinflammation (2023)

Here, we identify changes in the PI3K/AKT molecular signaling network and show how they participate in astrogliosis by regulating the HC protein Cx43. Moreover, because HC opening and ATP release are important in astrocyte reactivity, the phosphorylation of Cx43 by AKT and the associated increase in ATP release identify a potential therapeutic window of opportunity to limit the adverse effects of astrogliosis.

Keyphrases

protein kinase
signaling pathway
cell proliferation
high glucose
emergency department
drug induced
amino acid
adverse drug
stress induced