Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.
Jillian L EllisKevin E BoveErin G SchuetzDaniel LeinoC Alexander ValenciaJohn D SchuetzAlexander MiethkeChunyue YinPublished in: Hepatology (Baltimore, Md.) (2018)
Collectively, these data suggest a model that rapamycin rescues BSEP-deficient phenotypes by prompting alternative transporters to excrete bile salts; multidrug resistance protein 1 is a candidate for such an alternative transporter. (Hepatology 2018;67:1531-1545).