Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival.
Michael E CoulterDamir MusaevEllen M DeGennaroXiaochang ZhangKatrin HenkeKiely N JamesRichard S SmithR Sean HillJennifer N Partlownull Muna Al-SaffarA Stacy KamumbuNicole HatemA James BarkovichJacqueline AzizaNicolas ChassaingMaha S ZakiTipu SultanLydie BurglenAnna RajabLihadh Al-GazaliGaneshwaran H MochidaMatthew P HarrisJoseph G GleesonChristopher A WalshPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2020)
Our results highlight the essential role of the exocyst pathway in normal cortical development and how its perturbation causes complex brain disorders.