A deletion of IDUA exon 10 in a family of Golden Retriever dogs with an attenuated form of mucopolysaccharidosis type I.
Kiterie M E FallerAlison E RidyardRodrigo Gutierrez QuintanaAngie RuppCelia Kun-RodriguesTatiana OrmeKaren L TyleeHeather J ChurchRita GuerreiroJose BrasPublished in: Journal of veterinary internal medicine (2020)
Analysis of the genotype/phenotype correlation in this dog family suggests that dogs with MPS-I could have a less severe phenotype than humans, even in the presence of severe mutations. Treatment with pentosan polyphosphate should be considered in dogs with MPS-I.