Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats.

Gabriela ChyłaKornelia Sałaga-ZaleskaKamil DąbkowskiAgnieszka KuchtaMaciej Jankowski

Published in: Pharmacological reports : PR (2021)

Suramin increases the urinary excretion of VEGF-A in normoglycemia and hyperglycaemia, possibly without the involvement of MMP-9. Suramin may be used as a pharmacological tool enhancing VEGF-A urinary secretion.

Keyphrases

diabetic rats
oxidative stress
vascular endothelial growth factor
endothelial cells
high glucose
adipose tissue
cell migration
drug induced