Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.

Yanbo LiuZhen LiTianning SunZhixiao LiAnne ManyandeHongbing Xiang Zhigang He

Published in: CNS neuroscience & therapeutics (2024)

These findings suggest that acetate metabolism is impaired in the hippocampus of HIRI-induced cognitive impairment mice and related to dysbiosis, leading to compromised histone acetylation.

Keyphrases

cognitive impairment
ischemia reperfusion injury
high glucose
diabetic rats
high fat diet induced
drug induced
oxidative stress
dna methylation
endothelial cells
histone deacetylase
gene expression
metabolic syndrome
brain injury
skeletal muscle
wild type
subarachnoid hemorrhage
stress induced