Evaluation of the Interaction of Amino Acid Infusion on 177Lu-Dotatate Pharmacokinetics in Patients with Gastroenteropancreatic Neuroendocrine Tumors.

Alicja PuszkielMathilde Bauriaud-MalletRoxane BourgeoisLawrence DierickxFrédéric CourbonÉtienne Chatelut

Published in: Clinical pharmacokinetics (2020)

A substantial effect of AA co-infusion on 177Lu-Dotatate pharmacokinetics was shown but was associated with high IIV, contributing to IIV in hematological toxicity.

Keyphrases

neuroendocrine tumors
amino acid
low dose
oxidative stress
pet ct