17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury.

Yanling MaPhilip M BrownDennis D LinJing MaDechun FengOlga V BelyaevaMaren C PodszunJason RoszikJoselyn N AllenRegina UmarovaDavid E KleinerNatalia Y KedishviliOksana GavrilovaBin GaoYaron Rotman

Published in: Hepatology (Baltimore, Md.) (2021)

Extensive evaluation of Hsd17b13 deficiency in mice under several fatty liver-inducing dietary conditions did not reproduce the protective role of HSD17B13 loss-of-function mutants in human NAFLD. Moreover, mouse Hsd17b13 deficiency induces weight gain under RC. It is crucial to understand interspecies differences prior to leveraging HSD17B13 therapies.

Keyphrases

weight gain
body mass index
high fat diet induced
weight loss
birth weight
endothelial cells
replacement therapy
wild type
physical activity
type diabetes
metabolic syndrome
insulin resistance
preterm birth