Plasma biomarkers of Alzheimer's disease and related dementias in American Indians: The Strong Heart Study.
Astrid M Suchy-DiceyW T LongstrethKristoffer RhoadsJason UmansDedra BuchwaldThomas GrabowskiKaj BlennowEric ReimanHenrik ZetterbergPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
In American Indian individuals, pTau181 and Aβ values suggested more common pathology than in majority populations. Aβ was less informative than in other populations; however, all four markers were needed for a best-performing dementia diagnostic model. These data validate utility of AD plasma markers, while suggesting population-specific diagnostic characteristics.