The Role of Neuregulin-1 in Steatotic and Non-Steatotic Liver Transplantation from Brain-Dead Donors.

Marc Micó-Carnero Araní Casillas-RamírezAlfredo Sánchez-GonzálezCarlos Rojano-AlfonsoCarmen Peralta Uroz

Published in: Biomedicines (2022)

This study indicates the benefits of endogenous NRG1 in liver grafts from DBDs and underscores the specificity of the NRG1 signaling pathway depending on the type of liver: NRG1-PAK1-VEGFA in non-steatotic livers and NRG1-PAK1-IGF1 in steatotic livers. Exogenous NRG1 is not an appropriate strategy to apply to liver grafts from DBD.

Keyphrases

signaling pathway
pi k akt
epithelial mesenchymal transition
white matter
cell proliferation
resting state
functional connectivity
structural basis