Obesity promotes the expansion of metastasis-initiating cells in breast cancer.
Mélanie BousquenaudFlavia FicoGiovanni SolinasCurzio RüeggAlbert Santamaria-MartinezPublished in: Breast cancer research : BCR (2018)
These data indicate that a pro-metastatic effect of obesity is acquired by the tumor cells in the primary tumor independently of the microenvironment of the secondary site. Effects of postmenopausal obesity on primary breast cancer tumoursᅟ.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- induced apoptosis
- squamous cell carcinoma
- small cell lung cancer
- stem cells
- cell cycle arrest
- skeletal muscle
- body mass index
- electronic health record
- anti inflammatory
- big data
- cell proliferation
- machine learning
- oxidative stress
- postmenopausal women
- childhood cancer