Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition.

Xun WuJianing LuoHaixiao LiuWenxing CuiWei GuoLei ZhaoHao GuoHao BaiKang GuoDayun FengYan Qu

Published in: Cell proliferation (2020)

Our study provided the first evidence that APNp promoted neural survival following ICH injury in the diabetic setting and revealed a novel mechanism by which APNp suppressed mitochondrial and ATF4-CHOP apoptosis pathways in a Smad3 dependent manner.

Keyphrases

endoplasmic reticulum stress
oxidative stress
diffuse large b cell lymphoma
epithelial mesenchymal transition
transforming growth factor
cell cycle arrest
transcription factor
cell death
type diabetes
metabolic syndrome
single cell
skeletal muscle
signaling pathway
adipose tissue
subarachnoid hemorrhage