IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.

Taisuke UchidaYukio AkasakiTakuya SueishiIchiro KurakazuMasakazu ToyaMasanari KuwaharaRyota HiroseYuki HyodoHidetoshi TsushimaMartin K LotzYasuharu Nakashima

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

These results suggest that IKKε regulates cartilage degradation through a catabolic response mediated by NF-κB signaling, and is a potential target for OA treatment. Furthermore, BAY-985 may serve a major compound in drugs developed for OA. This article is protected by copyright. All rights reserved.

Keyphrases

knee osteoarthritis
extracellular matrix
signaling pathway
rheumatoid arthritis
oxidative stress
pi k akt
tyrosine kinase
nuclear factor
immune response
toll like receptor
climate change
drug induced