Chemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis.

Reported is the borono-Catellani arylation process for unsymmetrical biaryls synthesis, utilizing the readily available pinacol ester of arylboronic acids, aryl bromides, and olefins as the reactants. The distinct reactivity of arylboronic ester and aryl bromides secures the excellent chemoselectivity in the pivotal arylation step. The reaction is enabled by the cooperative catalysis of Pd(OAc)2 and the NBE derivative N7, with molecular oxygen as the terminal oxidant.