PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
Yu-Ching WenChien-Liang LiuHsiu-Lien YehWei-Hao ChenKuo-Ching JiangVan Thi Ngoc TramMichael HsiaoJiaoti HuangWei-Yu ChenYen-Nien LiuPublished in: British journal of cancer (2021)
Our study uncovers LIF/ZBTB46 signalling activation as a key mechanism for upregulating PCK1-driven glucose metabolism and neuroendocrine differentiation of CRPC, which may yield significant improvements in prostate cancer treatment after ADT using PCK1 inhibitors.
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