Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

Arti T Navare Fred D Mast Jean Paul Olivier Thierry Bertomeu Maxwell L NealLindsay N CarppAlexis KaushanskyJasmin Coulombe-HuntingtonMike TyersJohn D Aitchison

Published in: bioRxiv : the preprint server for biology (2020)

Using a viral-induced hypomorph of GBF1, Navare et al., demonstrate that the principle of synthetic lethality is a mechanism to selectively kill virus-infected cells.

Keyphrases

sars cov
induced apoptosis
cell cycle arrest
high glucose
single cell
climate change
diabetic rats
cell therapy
endoplasmic reticulum stress
protein protein
cell death
stem cells
amino acid
binding protein
signaling pathway
endothelial cells
mesenchymal stem cells
cell proliferation
small molecule