The mutational pattern of homologous recombination repair genes in urothelial carcinoma and its correlation with immunotherapeutic response.

Junru ChenYanfeng TangHuanhuan LiuGuangxi SunHaoyang LiuJunjie ZhaoZilin WangYanrui ZhangFeng LouShanbo CaoJia-Yue Qin Huina WangBanghua LiaoHao Zeng

Published in: Cancer medicine (2023)

Our findings provide valuable insights into the genomic landscape of Chinese UC patients and underscore the molecular rationale for utilizing immunotherapy in UC patients with HRR mutations.

Keyphrases

end stage renal disease
dna damage
dna repair
ejection fraction
chronic kidney disease
peritoneal dialysis
genome wide
copy number
dna methylation
single cell
gene expression
patient reported outcomes