Nuclear-specific accumulation of telomerase reverse transcriptase (TERT) mRNA in TERT promoter mutated follicular thyroid tumours visualised by in situ hybridisation: a possible clinical screening tool?

L Samuel HellgrenAnn OlssonAnn KaufeldtJohan O PaulssonMartin HysekAdam StenmanJan ZedeniusCatharina LarssonAnders HöögCarl Christofer Juhlin

Published in: Journal of clinical pathology (2021)

TERT mRNA seems to be focally expressed and localised exclusively to the nucleus in TERT promoter mutated follicular thyroid tumours, possibly reflecting a true biological and unorthodox phenomenon worthy of further investigations.

Keyphrases

dna methylation
transcription factor
gene expression
binding protein
wild type