In Vitro Susceptibility of Multi-Drug Resistant Klebsiellapneumoniae Strains Causing Nosocomial Infections to Fosfomycin. A Comparison of Determination Methods.
Beata MączyńskaJustyna PalecznyMonika Oleksy-WawrzyniakIrena Choroszy-KrólMarzenna BartoszewiczPublished in: Pathogens (Basel, Switzerland) (2021)
Fosfomycin appears to be the antibiotic with a potential for use in the treatment of infections with multidrug-resistant Klebsiella strains. Susceptibility to this drug is exhibited by some strains, which are resistant to colistin and carbapenems. The E-test, unlike the Phoenix method, can be an alternative to the reference method in the routine determination of fosfomycin susceptibility, as it shows agreement in terms of sensitivity categories and only slight differences in MIC values. The Phoenix system, in comparison to the reference method, shows large discrepancies in the MIC values and in the susceptibility category.
Keyphrases
- multidrug resistant
- drug resistant
- gram negative
- acinetobacter baumannii
- escherichia coli
- klebsiella pneumoniae
- urinary tract infection
- solid phase extraction
- pseudomonas aeruginosa
- molecularly imprinted
- clinical practice
- climate change
- risk assessment
- emergency department
- human health
- liquid chromatography
- combination therapy
- methicillin resistant staphylococcus aureus