Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic-pharmacodynamic model in gastrointestinal cancer patients.
Usman ArshadSu-Arpa PloylearmsaengMats O KarlssonOxana DoroshyenkoDorothee LangerEdgar SchömigSabine KunzeSemih A GünerRoman SkripnichenkoSami UllahUlrich JaehdeUwe FuhrAlexander JetterMax TaubertPublished in: Cancer chemotherapy and pharmacology (2020)
BSA should be taken into account for predicting 5FU exposure. Myelosuppression was influenced by 5FU exposure and concomitant administration of cisplatin.
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