Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants.

Waleed S Al AmriDiana E BaxterAndrew M HanbyLucy F SteadEldo T VergheseJames L ThorneThomas A Hughes

Published in: Breast cancer research and treatment (2020)

Genomic analysis of paired pre- and post-therapy samples resulting from neoadjuvant therapy provides a powerful method for identification of mediators of response. Genes we identified should be assessed as predictive markers or targets in chemo-sensitization.

Keyphrases

copy number
bioinformatics analysis
lymph node
locally advanced
rectal cancer
genome wide
photodynamic therapy
dna methylation
young adults
transcription factor
radiation therapy
drug delivery
mesenchymal stem cells
combination therapy
genome wide analysis