Toxoplasma gondii infection damages the perineuronal nets in a murine model.
Ywlliane da Silva Rodrigues MeurerRamayana Morais de Medeiros BritoValeria Palheta da SilvaJoelma Maria de Araujo AndadeSarah Sophia Guedes LinharesAntonio Pereira JuniorValter Ferreira de Andrade-NetoAndrea Lima de SáClaudio Bruno Silva de OliveiraPublished in: Memorias do Instituto Oswaldo Cruz (2020)
Our findings revealed a random distribution of cysts in the brain, the disruption of PNNs surrounding neurons in four areas of the cerebral cortex and hyperlocomotor behavior in T. gondii-infected mice. These results can contribute to elucidate the link toxoplasmosis with the establishment of neuroinflammatory response in neuropsychiatric disorders and to raise a discussion about the mechanisms related to changes in brain connectivity, with possible behavioral repercussions during chronic T. gondii infection.