Bis-benzylidine Piperidone RA190 treatment of hepatocellular carcinoma via binding RPN13 and inhibiting NF-κB signaling.

Ruey-Shyang SoongRavi K AnchooriRichard B S RodenRou-Ling ChoYi-Chan ChenSheng-Chieh TsengYun-Li HuangPo-Cheng LiaoYu-Chiau Shyu

Published in: BMC cancer (2020)

RA190 has therapeutic activity in a xenograft model, and with sorafenib exhibited synergetic killing of HCC cells in vitro, suggesting further exploration of such a combination treatment of HCC is warranted.

Keyphrases

signaling pathway
induced apoptosis
ankylosing spondylitis
combination therapy
cell death
endoplasmic reticulum stress
cell cycle arrest
smoking cessation