Assembly of Poly(vinylphosphonic acid)-Based Double Hydrophilic Block Copolymers by Gadolinium Ions for the Formation of Highly Stable MRI Contrast Agents.
Karolina Halina MarkiewiczLaurence MarmuseMargaux MounsamyClaire BilloteyMathias A DestaracChristophe MingotaudJean-Daniel MartyPublished in: ACS macro letters (2022)
Mixing double-hydrophilic block copolymers containing a poly(vinylphosphonic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are stable after dilution or change of pH and ionic strength. High magnetic relaxivities were measured in vitro, and in vivo magnetic resonance imaging on rats demonstrates the high potential of such polymeric assemblies.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- liquid chromatography
- drug delivery
- magnetic resonance
- computed tomography
- quantum dots
- cancer therapy
- diffusion weighted imaging
- drug release
- mass spectrometry
- photodynamic therapy
- liquid chromatography tandem mass spectrometry
- aqueous solution
- solid phase extraction
- water soluble
- risk assessment
- ionic liquid
- walled carbon nanotubes
- tandem mass spectrometry
- human health
- optic nerve
- ms ms
- optical coherence tomography
- high resolution