Myocardial fibrosis in asymptomatic and symptomatic chronic severe primary mitral regurgitation and relationship to tissue characterisation and left ventricular function on cardiovascular magnetic resonance.
Boyang LiuDesley A H NeilMonisha PremchandMoninder BhabraRamesh PatelThomas BarkerNicolas NikolaidisJ Stephen BillingThomas A TreibelJames C MoonArantxa GonzálezJames HodsonNicola C EdwardsRichard P SteedsPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2020)
Patients with chronic primary MR have increased fibrosis before the onset of symptoms. Due to the patchy nature of fibrosis, CMR derived ECV may be a better marker of global myocardial status. Clinical trial registration Mitral FINDER study; Clinical Trials NCT02355418, Registered 4 February 2015, https://clinicaltrials.gov/ct2/show/NCT02355418.
Keyphrases
- left ventricular
- clinical trial
- magnetic resonance
- contrast enhanced
- mitral valve
- hypertrophic cardiomyopathy
- acute myocardial infarction
- aortic stenosis
- left atrial
- heart failure
- cardiac resynchronization therapy
- phase ii
- open label
- computed tomography
- liver fibrosis
- sleep quality
- early onset
- physical activity
- depressive symptoms
- image quality
- phase iii
- magnetic resonance imaging
- acute coronary syndrome
- pet ct
- double blind
- placebo controlled