Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer.

Sofia C NunesFilipa Lopes-CoelhoSofia Gouveia-FernandesCristiano RamosSofia A PereiraJacinta Serpa

Published in: BMC evolutionary biology (2018)

We showed that cysteine impacts the adaptation of cancer cells to a CoCl2 mimicked hypoxic environment thus contributing for hypoxia-drived platinum-based chemotherapeutic agents' resistance, allowing the selection of more aggressive phenotypes. These observations support a role of cysteine in cancer progression, recurrence and chemoresistance.

Keyphrases

fluorescent probe
living cells
endothelial cells
papillary thyroid
squamous cell carcinoma
radiation therapy
free survival
young adults
childhood cancer
single molecule
open label
cancer stem cells
phase iii