Characterization of early communicative behavior in mouse models of neurofibromatosis type 1.
Susan E MaloneyKrystal C ChandlerCorina AnastasakiMichael A RiegerDavid H GutmannJoseph D DoughertyPublished in: Autism research : official journal of the International Society for Autism Research (2017)
Neurofibromatosis type 1 (NF1) is a common neurogenetic disorder caused by mutation of the NF1 gene, in which 80% of affected children exhibit cognitive and behavioral issues. Based on emerging evidence that NF1 may be an autism predisposition gene, we examined autism spectrum disorder (ASD)-relevant early communicative behavior in Nf1 mouse models and observed alterations in both models. The changes in early communicative behavior in Nf1 mutant mice should motivate further studies into the causative factors and potential treatments for ASD arising in the context of NF1.
Keyphrases
- autism spectrum disorder
- signaling pathway
- lps induced
- pi k akt
- nuclear factor
- oxidative stress
- intellectual disability
- mouse model
- attention deficit hyperactivity disorder
- inflammatory response
- genome wide
- copy number
- type diabetes
- toll like receptor
- immune response
- metabolic syndrome
- transcription factor
- risk assessment
- skeletal muscle
- human health
- genome wide identification
- working memory