M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways.

Si-Min ZhangChuan-Yuan WeiQiang WangLu WangLu LuFa-Zhi Qi

Published in: Molecular biology reports (2021)

Our research, for the first time, indicated that M2 promoted wound healing by secreting CTGF, which further mediating proliferation and migration of fibroblasts via AKT, ERK1/2, and STAT3 pathway.

Keyphrases

signaling pathway
wound healing
growth factor
cell proliferation
pi k akt
induced apoptosis
epithelial mesenchymal transition
extracellular matrix