Perturbations in Mitochondrial Dynamics Are Closely Involved in the Progression of Alcoholic Liver Disease.

Elena PalmaAntonio RivaChristophe MorenoGemma OdenaSatvinder MudanNikolai ManyakinRosa MiquelDelphine DegréEric TrepoPau Sancho-BruJose AltamiranoJuan CaballeriaAne ZamalloaKrishna MenonNigel HeatonRoger WilliamsRamon BatallerShilpa Chokshi

Published in: Alcoholism, clinical and experimental research (2020)

The present study reveals the role of mitochondrial dynamics in human ALD, confirming our previous observations in animal and cell culture models of ALD. Taken together, we show that alcohol has a significant impact on the fragmentation pathway, and we confirm Drp1 as a potential therapeutic target in severe ALD.

Keyphrases

oxidative stress
endothelial cells
liver injury
early onset
drug induced