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Proton Therapy for Partial Breast Irradiation: Rationale and Considerations.

J Isabelle ChoiJana FoxRichard BakstShaakir HasanRobert H PressArpit M ChhabraBrian YehCharles B Simone IiOren Cahlon
Published in: Journal of personalized medicine (2021)
In an era of continued advancements in personalized medicine for the treatment of breast cancer, select patients with early stage breast cancer may be uniquely poised to benefit from partial breast irradiation (PBI) delivered with proton therapy. PBI presents an opportunity to improve quality of life during treatment with a significantly shorter treatment duration. By targeting less non-target breast tissue, excess radiation exposure and resulting toxicities are also reduced. Proton therapy represents a precision radiotherapy technology that builds on these advantages by further limiting the normal tissue exposure to unnecessary radiation dose not only to uninvolved breast tissue but also the underlying thoracic organs including the heart and lungs. Herein, we present a concise review of the rationale for the use of proton therapy for PBI, evidence available to date, and practical considerations in the implementation and use of proton therapy for this indication.
Keyphrases
  • early stage
  • heart failure
  • radiation induced
  • primary care
  • clinical trial
  • spinal cord
  • perovskite solar cells
  • lymph node
  • combination therapy
  • breast cancer risk