Medication-related osteonecrosis of the jaw and successful implant treatment in a patient on high-dose antiresorptive medication: A case report.
Camilla OttesenSanne W M AndersenSimon S JensenThomas KofodKlaus GotfredsenPublished in: Clinical and experimental dental research (2022)
Peri-implantitis, and/or MRONJ, was diagnosed around two of the implants (23, 24), probably induced by crestal bone trauma from a healing abutment and/or a misfitting prosthetic reconstruction. A peri-implantitis operation was performed, but without the desired response, and the two implants (23, 24) were later removed in an MRONJ resection. The implants on the other side of the maxilla (14, 13) remained without complications. Dental implant treatment is feasible in patients on HDAR, but comorbidities (e.g., diabetes mellitus) and polypharmacy (e.g., chemotherapy and steroids) may add to the risk of implant failure. Minimal trauma surgery and prosthodontics are crucial to increase the chance of successful healing in an HDAR patient.
Keyphrases
- soft tissue
- high dose
- case report
- minimally invasive
- end stage renal disease
- ejection fraction
- newly diagnosed
- bone loss
- prognostic factors
- risk factors
- type diabetes
- bone mineral density
- radiation therapy
- skeletal muscle
- stem cell transplantation
- coronary artery bypass
- patient reported outcomes
- weight loss
- replacement therapy
- atrial fibrillation