68Ga-PSMA: a One-stop Shop in Radioactive Iodine Refractory Thyroid Cancer?

Thabo LenganaIsmaheel O LawalKgomotso MokoalaMariza VorsterMachaba Michael Sathekge

Published in: Nuclear medicine and molecular imaging (2019)

We report a case of a 47-year-old female known with metastatic papillary thyroid cancer. Her treatment history included total thyroidectomy and 3 previous radio ablations with a cumulative dose of 950 mCi of 131I. On follow-up, her thyroglobulin levels had demonstrated a rising trend (from 3789.0 to 4240.0 ug/L) despite a 123I whole-body scan demonstrating a reduction in tracer avid lesions. She was suspected of having radio-resistant disease. The patient underwent both 18F-FDG and 68Ga-PSMA PET/CT imaging with both scans demonstrating congruent lesions however with far greater intensity on the 68Ga-PSMA study.

Keyphrases

pet ct
positron emission tomography
computed tomography
dual energy
squamous cell carcinoma
high resolution
small cell lung cancer
case report
pulmonary embolism
mild cognitive impairment
high intensity
magnetic resonance
mass spectrometry
clear cell
fine needle aspiration
fluorescence imaging