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Two-pore channel protein TPC1 is a determining factor for the adaptation of proximal tubular phosphate handling.

Armin JustRobert T MallmannSonja GrossmannFaten SlemanNorbert Klugbauer
Published in: Acta physiologica (Oxford, England) (2023)
We conclude that TPC1 is expressed subapically in the proximal but not distal tubule and plays an important role in the dynamic adaptation of proximal tubular phosphate reabsorption towards enhanced, but not reduced absorption.
Keyphrases
  • high glucose