Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes.
Suzie J ScalesNidhi GuptaAnn M De MazièreGeorge PosthumaCecilia P ChiuAndrew A PierceKathy HötzelJianhua TaoOded ForemanGeorgios KoukosFrancesca OltrabellaJudith KlumpermanWeiYu LinAndrew S PetersonPublished in: Journal of the American Society of Nephrology : JASN (2020)
APOL1 is found in the ER and plasma membrane, consistent with either the ER stress or surface cation channel models of APOL1-mediated cytotoxicity. The surface localization of APOL1 variants potentially opens new therapeutic targeting avenues.