Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.
Allison L BartlettAdam LaneBrooklyn ChaneyNancy Yanez EscorzaKatie BlackAnne CochraneJane MinturnUte BartelsKathy WarrenJordan HansfordDavid ZieglerBlanca DiezStewart GoldmanRoger PackerMark KieranMariko D DeWireCraig ErkerMichelle Monje-DeisserothLars WagnerCarl J KoschmannKathleen DorrisChie-Schin ShihTim HassallYvan SamsonPaul FisherStacie S WangKaren TsuiGustavo SevleverXiaoting ZhuPhillip DexheimerAnthony AsherChristine FullerRachid DrissiBlaise JonesJames LeachMaryam FouladiPublished in: Neuro-oncology (2022)
Children ≤36 months demonstrated significantly more LTS, with an improved median OS of 15 months; 92% of LTS received radiation. Median OS in untreated children was 2 months, compared to 17 months for treated children. LTS had longer duration of symptoms. Excluded patients demonstrated a lower OS, contradicting the hypothesis that children ≤36 months with DIPG show improved outcomes due to misdiagnosis.