Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study.
Alexi N ArchambaultJihyoun JeonYi LinMinta ThomasTabitha A HarrisonD Timothy Timothy BishopHermann BrennerGraham CaseyAndrew T ChanJenny Chang-ClaudeJane C FigueiredoSteven GallingerStephen B GruberMarc J GunterFeng GuoMichael HoffmeisterMark E JenkinsTemitope O KekuLoic Le MarchandLi LiVictor MorenoPolly A NewcombRish K PaiPatrick S ParfreyGadi RennertLori C SakodaJeffrey K LeeMartha L SlatteryMingyang SongAung-Ko WinMichael O WoodsNeil MurphyPeter T CampbellYu-Ru SuIris Lansdorp-VogelaarElisabeth F P PeterseYin CaoAnne Zeleniuch-JacquottePeter S LiangMengmeng DuDouglas A CorleyLi HsuUlrike PetersRichard B HayesPublished in: Journal of the National Cancer Institute (2022)
Personal risk scores have the potential to identify individuals at differential relative and absolute risk for early-onset CRC. Improved discrimination may aid in targeted CRC screening of younger, high-risk individuals, potentially improving outcomes.