Gene Polymorphisms of Epithelial Cell-Derived Alarmins and Their Effects on Protein Levels and Disease Severity in Patients with COVID-19.

Maral RanjbarRuth P CusackChristiane E WhetstoneShiraz NawazChristopher KhouryJennifer WattieLesley WiltshireJennifer Le RouxEric ChengThivya SrinathanTerence HoRoma SehmiMyLinh DuongGail M Gauvreau

Published in: Genes (2023)

The present study highlights the importance of alarmin cytokines and genetic variations in COVID-19 severity, providing valuable insights into personalized treatment approaches. Our results suggest that targeting alarmin cytokines may offer potential therapeutic benefits in managing COVID-19. Furthermore, the sex-specific effects of genetic variations emphasize the need to consider individual genetic profiles and sex differences when designing targeted interventions.

Keyphrases

coronavirus disease
sars cov
genome wide
copy number
cancer therapy
physical activity
dna methylation
gene expression
combination therapy
protein protein