Triple ipso -defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols: access to fluoroalkylated orthoesters via C(sp 3 )-F bond cleavage.

Published in: Chemical communications (Cambridge, England) (2023)

The triple ipso -defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols by C(sp 3 )-F bond cleavage is reported, delivering various fluoroalkylated orthoesters in high yields. This reaction is transition-metal free and gram-scalable, features mild reaction conditions, and tolerates diverse functional groups.

Keyphrases

dna binding
electron transfer
gram negative
transcription factor