Asymmetric Synthesis of Axially Chiral Anilides via Organocatalytic Atroposelective N-Acylation.

A highly atroposelective N-acylation reaction of aniline-derived sulfonamides has been developed with chiral isothiourea as the catalyst. This approach provides a facile and efficient route to an array of atropoisomeric sulfonyl substituted anilide products in good yields with high to excellent enantioselectivities.