MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

Natsumi TsuboyamaAileen Patricia SzczepanskiZibo ZhaoLu Wang

Published in: Genome biology (2022)

We characterize MBD5 and MBD6 as important regulators of the BAP1 complex and maintain its transcriptional landscape, shedding light on the therapeutic potential of targeting MBD5 and MBD6 in BAP1-dependent human cancers.

Keyphrases

endothelial cells
transcription factor
gene expression
papillary thyroid
oxidative stress