Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii.
Leah M C McgeeAlemao G Carpinteyro SanchezMarina PerieteanuKaveh EskandariYan BianLogan MackieLouise YoungRebecca BeveridgeColin J SucklingCraig W RobertsFraser J ScottPublished in: The Journal of antimicrobial chemotherapy (2024)
Together, these data provide confidence that S-MGBs can be further optimized to generate new, potent treatments for Acanthameoba spp. infections. In particular, S-MGB-241, has been identified as a 'hit' compound that is selectively active against A. castellanii, providing a starting point from which to begin optimization of DNA binding and potency.