Functional microRNA targetome undergoes degeneration-induced shift in the retina.

Joshua A Chu-TanAdrian V CioancaZhi-Ping FengYvette WooffUlrike SchumannRiemke Aggio-BruceHardip PatelMatt RutarKatherine HannanKonstantin PanovJan ProvisRiccardo Natoli

Published in: Molecular neurodegeneration (2021)

This study provides important insight into the alteration of miRNA regulatory activity that occurs as a response to retinal degeneration and explores the miRNA-mRNA targetome as a consequence of retinal degenerations. Further characterisation of these miRNA/mRNA interactions in the context of the degenerating retina may provide an important insight into the active role these miRNA may play in diseases such as AMD.

Keyphrases

diabetic retinopathy
optic nerve
optical coherence tomography
transcription factor
binding protein
high glucose
oxidative stress
diabetic rats
age related macular degeneration