"Switched" metabolic acidosis in mitochondrial diabetes mellitus.

Yamato KeidaiYorihiro IwasakiSachiko HonjoMegumi Aizawa-AbeKanako IwasakiAkihiro Hamasaki

Published in: Journal of diabetes investigation (2019)

A patient with mitochondrial diabetes mellitus developed diabetic ketoacidosis. During insulin treatment, although diabetic ketoacidosis improved, lactic acidosis unexpectedly worsened. This clinical course, named "switched metabolic acidosis," could reflect the unique pathophysiology of the mitochondrial disorder.

Keyphrases

type diabetes
oxidative stress
glycemic control
combination therapy
smoking cessation