Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells.

Ewelina Piktel Karolina Halina MarkiewiczAgnieszka Z WilczewskaTamara DanilukSylwia ChmielewskaKatarzyna Niemirowicz-Laskowska Joanna MystkowskaPaulina PaprockaPaul B Savage Robert Bucki

Published in: International journal of nanomedicine (2020)

Comparative analyses have revealed that both developed CSA-containing nanoformulations due to the utility of synergistic interactions between MNP and CSA-131, which are effective against lung and colon cancer cells. This indicates the new directions in preparation of MNP-based therapeutics, which are relatively easy to synthetize, cost-effective and safe when intravenously administrated.

Keyphrases

magnetic nanoparticles
iron oxide
cancer therapy
small molecule
drug delivery
mass spectrometry
high resolution